FOOD SUPPLEMENT | MINISTERIAL CODE: 165403
PRODUCT DESCRIPTION
The formulation of Probenat® GZ has been specially designed to meet the needs of pregnant women, with a combination of essential micronutrients during pregnancy and substances that support the normal function of the maternal and fetal vascular system.
L-Arginine and L-Citrulline are amino acids involved in the cyclical process of synthesis of nitric oxide (NO), a molecule naturally produced by our body, important in maintaining the integrity of the endothelium (tissue that lines the internal surface of blood vessels). In fact, Nitric oxide is involved in the processes of vasodilation and inhibition of platelet aggregation.
The dry extract of Willow, with its Salicin content, is useful for contrasting localized states of tension. Furthermore, once Salicin is taken, it is metabolized into salicylic acid, a substance known for its antiplatelet aggregation properties.
Magnesium (Magshape®), Iodine and Vitamins B12 and C contribute to normal energy metabolism. Folate (QUATREFOLIC® contributes to the growth of maternal tissues during pregnancy. Magnesium, folate and Vitamins C and B12 contribute to the reduction of tiredness and fatigue. Folate and Vitamins D and B12 intervene in the cell division process. Vitamin C contributes to the protection of cells from oxidative stress.
INGREDIENTS
Food supplement based on L-Arginine, L-Citrulline, Willow Extract, Magnesium, Iodine, Vitamin C, Vitamin D, Vitamin B12 and Folate.
PRODUCT SPECIFICATIONS
HOW TO USE
It is recommended to take 1 sachet twice a day. Pour the contents of the sachet into a glass of water (200 ml), mix well and take immediately.
Probenat® GZ has a characteristic pink color and a delicate pomegranate aroma.
NUTRITION FACTS
| Ingredients | Per daily dose (2 sachets) | %NRV* |
| L-Arginine | 1000 mg | – |
| L-Citrulline | 1000 mg | – |
| Magnesium | 350 mg | 93 |
| Iodine | 225 mcg | 150 |
| Willow bark d.e. | 100 mg | – |
| – of which Salicin | 30 mg | – |
| Vitamin C | 100 mg | 125 |
| Vitamin D | 25 mcg | 500 |
| Vitamin B12 | 2.6 mcg | 104 |
| Folate | 400 mcg | 200 |
*NRV: Nutrient Reference Value according to Reg (EU) 1169/2011
Magshape® is a trademark of Lubrizol Advanced Materials, Inc. or its affiliates.
Quatrefolic® is a registered trademark of Gnosis S.p.A.
Warnings
Keep out of the reach of children under three years of age. Do not exceed the recommended dose. Food supplements are not intended as substitutes for a varied and balanced diet and a correct lifestyle. If you are taking antiplatelet or anticoagulant drugs, it is advisable to seek the opinion of your doctor. Not recommended for use by children and adolescents. Excessive consumption can have laxative effects.
Hypertension in pregnancy
Blood pressure-related pathologies during pregnancy represent one of the most common health problems with possible adverse events for both the mother and the fetus/newborn. For this reason, monitoring, especially in future mothers with risk factors, is an important prevention action. To diagnose hypertension during pregnancy, it is advisable to undergo regular blood pressure measurements during monthly medical visits.
Often “hypertension in pregnancy” is equivalent to indicating a syndrome that can arise in the second half of pregnancy itself and which goes by the name of “GESTOSIS”. The latter is in fact characterized, in its most complete clinical expression, by 3 main symptoms which are: Edema, Proteinuria and Hypertension (EPH). In fact, in its most complete sense, polysymptomatic gestosis (with all three symptoms) is also called as (EPH, Edema, Proteinuria, Hypertension). Infatti nella sua accezione più completa, la gestosi polisintomatica (cioè con tutti e tre i sintomi) viene anche indicata come gestosi EPH.
PREECLAMPSIA represents a worsening state of EPH gestosis in which, in addition to the increase in blood pressure, edema and proteinuria, subjective disorders also occur such as e.g. headache, epigastric pain, visual and gastrointestinal disorders (nausea and vomiting) due to a situation of generalized vasospasm in various districts.
The“GREY ZONE” represents the area in which pregnant patients at low-medium risk of preeclampsia are located who, despite not having the requirements for pharmacological therapy (based on salicylates or heparin), could benefit from quality supplementation.
PROBENAT® GZ (GZ = GREY ZONE) represents the unique supplement during pregnancy, with an association of essential micronutrients (vitamins and minerals) during gestation and substances that support the normal function of the maternal and fetal vascular system, useful for preventing GESTOSIS EPH /PREECLAMPSIA.
Among its ingredients there are:
- L-Arginine e L-Citrulline: amino acids involved in the cyclic process of synthesis of nitric oxide (NO), an important molecule in maintaining the integrity of the endothelium (tissue that lines the internal surface of blood vessels). In fact, Nitric oxide is involved in the processes of vasodilation and inhibition of platelet aggregation.
Scientific studies have shown that the intake of L-Arginine in pregnant women at risk can1,2:
- REDUCE MATERNAL BLOOD PRESSURE AND THE INCIDENCE OF PREECLAMPSIA
- REDUCE CASES OF PRETERM BIRTH
- PROMOTE A HIGHER BIRTH WEIGHT and IMPROVE THE APGAR INDEX (indicator of the health of the newborn in the first moments of life).
- Willow extract, with its Salicin content, reduces platelet aggregation.
- Magnesium:mineral with muscle relaxant properties. It contributes to normal muscle function, normal energy metabolism and electrolyte balance.
The Magnesium present in PROBENAT®GZ is the innovative patent MAGSHAPE® microcapsules, a micronized and microencapsulated magnesium. This new technology gives Magnesium high absorption and high bioavailability compared to other forms of Magnesium.
- Folate:contributes to the growth of maternal tissues during pregnancy. Supplementary intake of folic acid increases maternal folate status. Low maternal folate status is a risk factor for the development of neural tube defects in the fetus (the beneficial effect is obtained with a daily supplementary intake of folic acid of 400 μg for at least one month before and up to three months after conception).
Folic acid as such is not active, but is the precursor of the active form 5-methyltetrahydrofolate (5-MTHF). The folate present in Probenat® GZ is the innovative patent QUATREFOLIC® (glucosamine salt of (6S)-5-methyltetrahydrofolate), the active form of folic acid.
- Iodine:essential mineral for the proper functioning and health of the thyroid gland.
- Vitamin C: its serum concentration is reduced in pregnant women with preeclampsia3 and also prevents placental oxidative stress.
- Vitamin D: during pregnancy it can reduce the risk of preclampsia4.
- Vitamin B12: water-soluble vitamin that contributes to normal energy metabolism and the reduction of tiredness and fatigue.
References:
- Camareda Pulido E.E. et al., Hypertens Pregnancy. 2016; 35(2):217-225.
- Weckman A.M. et al., Adv Nutr. 2019; 10(5):765-777.
- Bowen R.S. et al., J Obstet Gynaecol. 1998; 18(1):9-13.
- Fogacci S. et al., Clin Nutr. 2020; 39(6):1742-1752.
Blood pressure level is one of the most important indicators of health during pregnancy, yet it is not always sufficiently monitored. Blood pressure during pregnancy should be monitored frequently, even when there have never been problems before. To be within the norm, the minimum (diastolic) and maximum (systolic) pressure values must remain below 90 and 140 mmHg. If systolic values >180 mmHg and/or diastolic values >100 mmHg occur during monitoring, you should contact your gynecologist and/or cardiologist to quickly reduce blood pressure and set the most appropriate therapy. What every pregnant woman should do in order to minimize the possibility of developing a hypertensive condition is to take care of herself and her baby with simple behavioural rules:
- Use salt in moderation in the diet. Therefore, avoid ready-to-eat foods or foods containing them large quantities (e.g. cheese);
- Avoid the consumption of coffee and alcohol;
- Do moderate physical activity (at least 150 minutes a week), unless otherwise indicated by the gynecologist;
- Avoid stressful conditions;
- Undergo clinical checks to monitor fetal well-being.
