In this day, every year, a theme is chosen: for 2022 it is the mental health. Indeed, a quarter of people living with psoriatic disease experience depression. Talking about anxiety, the number rises to 48%.
In fact, very often cutaneous manifestations are object of fixed gazes, hesitations, abnormal attitudes and behaviors toward affected people.
Psoriasis is a chronic inflammatory disease of the skin characterized by hyperproliferation of keratinocytes with inflammation of the epidermis and dermis. The etiology is multifactorial: genetic predisposition, immune and environmental factors (stress, trauma, drugs, alcohol, abuse of nicotine). To date there is not cure.
Did you know that…
There is an association between psoriasis and hyperhomocysteinemia.
In fact, several studies show that in patients with psoriasis there are:
- Higher homocysteine plasma levels than the control: probably for a reduction of folic acid and vitamin B12, which are involved in the homocysteine metabolism ;
- Direct proportionality between the severity of the disease and homocysteine plasma levels [2-5];
- Alterations of the production of hydrogen sulfide (H2S) which is involved in dermatological diseases, including psoriasis ; H2S participates in various functions at the cutaneous level such as the control of itching or the reduction of neutrophils at the site of the lesion. In case of hyperhomocysteinemia, the activity of the enzymes involved in the production of cysteine is reduced and consequently the levels of H2S are lower .
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References: Xiran Lin, Xianmin Meng, Zhiqi Song; Homocysteine and psoriasis. Biosci Rep 29 November 2019; 39 (11).  Refsum et al., (1989) Fasting plasma homocysteine as a sensitive parameter of antifolate effect: a study of psoriasis patients receiving low-dose methotrexate treatment. Clin. Pharmacol. Ther. 46, 510–520.  Shalaby et al., (2017) Homocysteine Serum Status in Patients with Psoriasis Vulgaris. N. Y. Sci. J. 10, 29–32  Malerba et al., (2006) Plasma homocysteine and folate levels in patients with chronic plaque psoriasis. Br. J. Dermatol. 155, 1165–1169, Erratum in: Br J Dermatol. 2007 Feb; 156: 410.  Giannoni et al., (2015) Homocysteine plasma levels in psoriasis patients: our experience and review of the literature. J. Eur. Acad. Dermatol. Venereol. 29, 1781–1785, Epub 2015 Mar 23.  Coavoy‐Sánchez et al., (2019). HYDROGEN SULFIDE AND DERMATOLOGICAL DISEASES. British Journal of Pharmacology, (), bph.14699